Joseph Smyly's Notebook begins with commonplace book material on common ailments and their treatment, and observation, for example:

'Women bear operations better than men every old woman that Mr Wilmot operated on recovered.'; 'Hypochondriacs have a great inclination to impose on there [sic] physicians a case is related in which a female collected a number of stones such as quartz and coloured them with faeces and showed them to her physician who immediately set them down as gall-stones'.

Also contains a description of attempts to relieve the suffering of Miss Reid, a 23 year old girl, only daughter of David Reid esquire of Mill Bank, Fermoy, near Cork, and about to be married, who died of burns two days after catching fire when the cape of her dressing grown approached too near the candle.

Also some correspondence and notes about insurance's and payments of fees.

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